Kevin Pho, MD 2/25/2026

Insulin resistance is not a disease: a metabolic reframe

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The article argues that type 2 diabetes and metabolic disease stem from chronically elevated blood sugar, not from defective biology or 'insulin resistance.' It reframes reduced cellular glucose uptake as a protective, regulated response to energy oversupply. The piece critiques the standard medical focus on increasing insulin and medications instead of addressing the root cause: dietary patterns that chronically overload the body with glucose.

Insulin resistance is not a disease: a metabolic reframe

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